Health Technology Assessment in Action

Published by: Kowsar

Safety and Effectiveness of Superficial Radiation Therapy in the Treatment of Skin Diseases: A Systematic Review

Pejman Hamouzadeh 1 , Shokofe Darkhor 2 , Parisa Aboie 3 , Mohsen Zare 4 and Serajaddin Gray 1 , *
Authors Information
1 Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2 Yahyanejad Hospital, Babol University of Medical Sciences, Babol, Iran
3 National Institute for Health Research, Tehran, Iran
4 Department of Financial Management, Faculty of Management and Economics, Islamic Azad University, Science and Research Branch, Tehran, Iran
Article information
  • Health Technology Assessment in Action: April 2017, 1 (1); e62068
  • Published Online: April 28, 2017
  • Article Type: Review Article
  • Received: February 3, 2017
  • Revised: March 19, 2017
  • Accepted: April 20, 2017
  • DOI: 10.5812/htaa.62068

To Cite: Hamouzadeh P, Darkhor S, Aboie P, Zare M, Gray S. Safety and Effectiveness of Superficial Radiation Therapy in the Treatment of Skin Diseases: A Systematic Review, Health Tech Asmnt Act. 2017 ; 1(1):e62068. doi: 10.5812/htaa.62068.

Copyright © 2017, Health Technology Assessment in Action. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Context
2. Methods
3. Results
4. Discussion
  • 1. Malmir S, Mowlavi A, Mohammadi S. Evaluation of dose enhancement in radiosensitizer aided tumor: A study on influential factors. Rep Radiother Oncol. 2015;2(4). doi: 10.5812/rro.11076.
  • 2. Grossi Marconi D, da Costa Resende B, Rauber E, de Cassia Soares P, Fernandes J, Mehta N, et al. Head and Neck Non-Melanoma Skin Cancer Treated By Superficial X-Ray Therapy: An Analysis of 1021 Cases. PLoS One. 2016;11(7). e0156544. doi: 10.1371/journal.pone.0156544. [PubMed: 27367229].
  • 3. Zhang P, Qiao Y, Xia J, Guan J, Ma L, Su M. Enhanced radiation therapy with multilayer microdisks containing radiosensitizing gold nanoparticles. ACS Appl Mater Interfaces. 2015;7(8):4518-24. doi: 10.1021/am506866a. [PubMed: 25679345].
  • 4. Jones ME, Hardy C, Ridgway J. Keloid Management: A Retrospective Case Review on a New Approach Using Surgical Excision, Platelet-Rich Plasma, and In-office Superficial Photon X-ray Radiation Therapy. Adv Skin Wound Care. 2016;29(7):303-7. doi: 10.1097/01.ASW.0000482993.64811.74. [PubMed: 27300360].
  • 5. Soyer HP, Rigel D, Wurm EMT. Dermatology. Actinic Keratosis, Basal Cell Carcinoma and Squamous Cell Carcinoma. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. 3 ed. Edinburgh, Scotland: Elsevier Saunders; 2012. p. 1773-94.
  • 6. McGregor S, Minni J, Herold D. Superficial Radiation Therapy for the Treatment of Nonmelanoma Skin Cancers. J Clin Aesthet Dermatol. 2015;8(12):12-4. [PubMed: 26705443].
  • 7. Rowell N. Adverse effects of superficial X-ray therapy and recommendations for safe use in benign dermatoses. J Dermatol Surg Oncol. 1978;4(8):630-4. doi: 10.1111/j.1524-4725.1978.tb00514.x. [PubMed: 690314].
  • 8. Johnstone CD, LaFontaine R, Poirier Y, Tambasco M. Modeling a superficial radiotherapy X-ray source for relative dose calculations. J Appl Clin Med Phys. 2015;16(3):5162. doi: 10.1120/jacmp.v16i3.5162. [PubMed: 26103479].
  • 9. Rowell NR. A follow-up study of superficial radiotherapy for benign dermatoses: recommendations for the use of X-rays in dermatology. Br J Dermatol. 1973;88(6):583-90. doi: 10.1111/j.1365-2133.1973.tb08023.x. [PubMed: 4717414].
  • 10. Macht SH, Cordero JM. Superficial radiotherapy of warts: results of treating 531 warts. Radiology. 1977;122(1):231-2. doi: 10.1148/122.1.231. [PubMed: 830341].
  • 11. Fairris GM, Mack DP, Rowell NR. Superficial X-ray therapy in the treatment of constitutional eczema of the hands. Br J Dermatol. 1984;111(4):445-9. doi: 10.1111/j.1365-2133.1984.tb06607.x. [PubMed: 6386031].
  • 12. Fairris GM, Jones DH, Mack DP, Rowell NR. Superficial radiotherapy for benign localized dermatoses. Br J Dermatol. 1984;111(Suppl 26):19. doi: 10.1111/j.1365-2133.1984.tb05236.x.
  • 13. Fairris GM, Jones DH, Mack DP, Rowell NR. Superficial X-ray therapy in the treatment of palmoplantar pustulosis. Br J Dermatol. 1984;111(4):499-500. doi: 10.1111/j.1365-2133.1984.tb06607.x. [PubMed: 6386034].
  • 14. Fairris GM, Jones DH, Mack DP, Rowell NR. Superficial X-ray therapy in the treatment of constitutional eczema of the feet. Br J Dermatol. 1984;111(4):500-2. doi: 10.1111/j.1365-2133.1984.tb06607.x. [PubMed: 6386035].
  • 15. King CM, Chalmers RJ. A double-blind study of superficial radiotherapy in chronic palmar eczema. Br J Dermatol. 1984;111(4):451-4. doi: 10.1111/j.1365-2133.1984.tb06608.x. [PubMed: 6386032].
  • 16. Fairris GM, Jones DH, Mack DP, Rowell NR. Conventional superficial X-ray versus Grenz ray therapy in the treatment of constitutional eczema of the hands. Br J Dermatol. 1985;112(3):339-41. doi: 10.1111/j.1365-2133.1985.tb04862.x. [PubMed: 3884032].
  • 17. Ashby MA, Smith J, Ainslie J, McEwan L. Treatment of nonmelanoma skin cancer at a large Australian center. Cancer. 1989;63(9):1863-71. [PubMed: 2702595].
  • 18. Sheehan-Dare RA, Goodfield MJ, Rowell NR. Topical psoralen photochemotherapy (PUVA) and superficial radiotherapy in the treatment of chronic hand eczema. Br J Dermatol. 1989;121(1):65-9. doi: 10.1111/j.1365-2133.1989.tb01401.x. [PubMed: 2757957].
  • 19. Griep C, Davelaar J, Scholten AN, Chin A, Leer JW. Electron beam therapy is not inferior to superficial x-ray therapy in the treatment of skin carcinoma. Int J Radiat Oncol Biol Phys. 1995;32(5):1347-50. doi: 10.1016/0360-3016(94)00603-I. [PubMed: 7635774].
  • 20. Berridge JK, Morgan DA. A comparison of late cosmetic results following two different radiotherapy techniques for treating basal cell carcinoma. Clin Oncol (R Coll Radiol). 1997;9(6):400-2. doi: 10.1016/S0936-6555(97)80137-9. [PubMed: 9448970].
  • 21. Maghsudi M, Mohamadi S. A study on the relationship between job burnout and couple burnout of female g ynecologists (case study: Tehran). Women Dev Polit. 2010;8(3):57-71. Persian.
  • 22. Veness M, Richards S. Dermatology. Radiotherapy. 2. Basel, Switzerland; 2012. p. 2291-301.
  • 23. David CV. Electronic brachytherapy and superficial radiation therapy: will you be adding it to your practice? Cutis. 2013;92(5):E16-8. [PubMed: 24343219].
  • 24. Phillips B, Ball C, Badenoch D, Straus S, Haynes B, Dawes M. Oxford centre for evidence-based medicine levels of evidence (May 2001). BJU Int. 2011;107(5):870. doi: 10.1111/j.1464-410X.2011.10141.x. [PubMed: 28640539].
  • 25. Cherla DV, Olavarria OA, Bernardi K, Viso CP, Moses ML, Holihan JL, et al. Investigation of Financial Conflict of Interest among Published Ventral Hernia Research. J Am Coll Surg. 2018;226(3):230-4. doi: 10.1016/j.jamcollsurg.2017.12.009. [PubMed: 29274839].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments